Individual Heterogeneity in Platelet Response to Lysophosphatidic Acid

Individual heterogeneity in platelet response to lysophosphatidic acid: evidence for a novel inhibitory pathway.

OBJECTIVE The bioactive lipid lysophosphatidic acid (LPA) stimulates platelet actin reorganization, adhesion, shape change, and aggregation. LPA is present in blood and exposure or release of LPA after atherosclerotic plaque rupture has been proposed to trigger platelet thrombus formation. METHODS AND RESULTS In this report, we characterize heterogeneity in LPA responses among individuals. Pl...

Platelet-derived lysophosphatidic acid decreases endothelial permeability in vitro.

We previously reported that platelets release a soluble factor that decreases the solute permeability of cultured bovine aortic endothelial monolayers. This factor was characterized as heat stable, trypsin sensitive, and not serotonin, adenosine, ADP, or ATP [F. R. Haselton and J. S. Alexander. Am. J. Physiol. 263 ( Lung Cell Mol. Physiol. 7): L670-L678, 1992]. We now report its identity as lys...

Platelet response heterogeneity in thrombus formation.

Vascular injury leads to formation of a structured thrombus as a consequence of platelet activation and aggregation, thrombin and fibrin formation, and trapping of leukocytes and red cells. This review summarises current evidence for heterogeneity of platelet responses and functions in the thrombus-forming process. Environmental factors contribute to response heterogeneity, as the platelets in ...

Platelet activation and platelet- monocyte aggregate formation induced by the atherosclerotic plaque lipid lysophosphatidic acid

Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin.

Gelsolin is a highly conserved intracellular actin-binding protein with an extracellular isoform, plasma gelsolin (pGSN). Blood concentrations of pGSN decrease in response to diverse tissue injuries. Depletion of pGSN to critical levels precedes and often predicts complications of injuries such as lung permeability changes and death. Administration of recombinant pGSN ameliorates such complicat...